Carob seed extract (Ceratonia siliqua) rich in oligogalactomannans.
Selected for its ability to regulate epidermal and dermal growth factors to help with the natural regeneration of skin microlesions.
Activins belong to the TGF-β family and they play an important role in the morphogenesis of the skin. In the event of a lesion, activin A, secreted by the keratinocytes, promotes re-epithelialisation by stimulating proliferation and differentiation of the keratinocytes.
In the dermis, TGF-β1 stimulates fibroblast proliferation; it boosts the matrix depositions and induces the synthesis of α-SMA and therefore the differentiation of fibroblasts into myofibroblasts.
α-SMA, the actin isoform of the muscle cells, gives myofibroblasts the ability to generate contractile forces which are important for ensuring the lesion closes and actively participate in tissue repair.
It has been proven that GlycorepairTM:
– regulates the synthesis TGF-β1 growth factors (mediators of dermal and epidermal repair) and activin A (mediator of mainly epidermal repair) naturally involved in the skin regeneration process.
Synthesis of activin A: +93%
Synthesis of TGF-β1:+17%
– stimulates the synthesis of α-SMA that promotes the contractile power of myofibroblasts and therefore participates in dermal repair.
– restores the migratory potential of fibroblasts and keratinocytes, boosting the recolonisation of damaged dermal and epidermal tissue.
🡺 Glyco-RepairTM speeds up the capacity of skin weakened by external factors to repair itself and recover.
🡺The skin regains its optimal barrier level and recovers its other essential functions.
Present in: RA Regenerative ampoules/ REP Repair balm/ RS Regenerative solution
ESSENTIAL OBJECTIVE: REGENERATE
Contribute a skin growth factor analogue
Tripeptide GF 2%
The HGF growth factor is known in particular for its ability to regulate cell growth and mobility, and it plays a central role in tissue regeneration.
When it was discovered, scientists thought that its effect was limited to hepatocytes, but it was then shown that it acts on numerous other cell types. The multiplicity of the targets of HGF can be explained by the fact that numerous epithelial or endothelial cells have an HGF receptor on their surface.
It has now been established that apart from adult hepatocytes, HGF stimulates the proliferation of the cells of numerous epithelial lines such as keratinocytes.
Tripeptide GF is a peptide in a solution. This tripeptide has been selected by Sothys Advanced Research because it is a messenger, biomimetic or analogue peptide of the HGF growth factor.
Its structure is similar to the peptide sequence of the natural precursor to the synthesis of collagen, and it is able to contribute to the regeneration of the extracellular matrix.
It has therefore been proven that this biomimetic tripeptide demonstrates the following actions:
- activates the production of the proteins of the extracellular matrix as well as DEJ proteins
- Active ingredient found in yeast, rich in polysaccharides and vitamin PP
- Stimulates the VEGF, the growth factor of the vascular endothelium, thus contributing to the restructuring and organisation of the blood capillary network
- Increases the resistance of vessels with its high concentration of vitamin PP
- promotes neovascularisation
- It also reduces vascular congestion and helps restructure the capillary network to facilitate blood circulation.
- It has been proven that the VEGF booster:
- improves the quality and organisation of the vascular network (tests on endothelial cells)
- increases the synthesis of VEGF (vascular endothelium growth factor) by 60% – test on keratinocytes.